The Government of Mexico announced the signing of a purchase agreement for Pfizer’s oral antiviral therapy against Covid-19, called Paxlovid.
The contract completes the acquisition of 300,000 oral treatments which have already begun their arrival in the country.
Pfizer’s antiviral treatment, focused on being administered to people who have the disease caused by the SARS-CoV-2 virus and who are at high risk of developing complications, was approved by the Federal Commission for the Protection against Sanitary Risks ( Cofepris ) last January 2022, being the first health regulatory agency in Latin America to approve it, and the second country in the region to be supplied.
The treatment includes nirmatrelvir, a protease inhibitor that was specifically designed to block the activity of SARS-CoV-2 protease 3CL, an enzyme that the coronavirus needs to replicate.
Data show that this treatment reduces the risk of hospitalization or death by 89% when started within three days of symptom onset and by 88% when started within the fourth to fifth day of symptom onset, compared to a placebo test group.
Constanza Losada, president and CEO of Pfizer Mexico, said that this agreement helps them continue working hand in hand with the Government of Mexico to address this public health crisis.
“The fight and commitment to end the effects of the pandemic is everyone’s task and this is reflected in the agreement we have signed to continue seeking the well-being of people,” he said.
To date, Pfizer has supplied more than 26.2 million oral treatments against Covid-19 to 41 countries.
Co-administration with a low dose of ritonavir helps slow down the metabolism or breakdown of nirmatrelvir so that it remains active in the body longer at higher concentrations to help fight the virus.
Pfizer noted that nirmatrelvir showed no evidence of mutagenic interactions with DNA .
Nirmatrelvir has shown consistent antiviral activity in vitro against former and current variants such as Alpha, Beta, Delta, Gamma, Lambda, Mu, and omicron.
It is a drug produced by the pharmaceutical company Pfizer and recommended by the World Health Organization (WHO) to treat the early stages of the Covid-19 disease in patients at risk of hospitalization, such as the elderly, immunosuppressed, or unvaccinated.
Paxlovid actually consists of two drugs, nirmatrelvir and ritonavir. The former is an antiviral and the latter is a pharmacokinetic enhancer.
Paxlovid is only recommended for adults and adolescents 12 years of age and older.
The oral antiretroviral drug from the Pfizer laboratory is administered in the early stages of the disease when serious symptoms have not yet developed. One tablet is taken orally every 24 hours for five days. According to the WHO, it is indicated for patients “with non-severe forms of Covid-19 who are at high risk of evolving into severe forms of the disease and of being hospitalized, such as unvaccinated, elderly or immunosuppressed patients.”
One of the biggest questions that experts raised about the drug is the “rebound” effect that was seen in some patients after taking it. Fauci himself experienced this phenomenon, when after three days of negative rapid tests for Covid-19, he contracted the virus again, manifesting some mild symptoms such as low-grade fever, sore throat, and body aches.
Fauci, however, persisted in his defense of Paxlovid, arguing that the drug served “its original purpose” which was to prevent his hospitalization. “It’s not meant to prevent rebounds. It is meant to prevent you from being hospitalized. I’m 81 years old, I was at risk of hospitalization and I wasn’t even sick enough to be hospitalized,” Fauci told reporters.
Early this week, US President Joe Biden also experienced a COVID-19 rebound after being treated with the drug and testing negative.
Subscribe here to receive our newsletters, Whatsapp emergency alerts, access exclusive content on PVDN, and enjoy this site with fewer ads for only $25 USD per year! (.06 cents per day)
Trending Stories Right Now on PVDN
- Criminals gangs burn stores and vehicles in Jalisco and Guanajuato Terror took hold of Jalisco and Guanajuato on Tuesday night. Criminals burned cars, trucks, and businesses, and also blocked several roads in these two states just after 7:00 p.m. The violence was the response to the operation to arrest a regional criminal and the clashes between crime rings and members of the Army, as explained…
- Mexico governmental agency investigates Sonora Grill for accusations of separating diners by skin color The luxury restaurant chain Sonora Grill Group is in the eye of the hurricane due to accusations that point to alleged acts of discrimination and racism against its diners. The accusations started at the restaurant chain’s location on Presidente Masaryk street in the Polanco neighborhood -one of the most exclusive in the capital-, where they…
- Allegations that Amber Heard blackmailed Elon Musk to pay Johnny Depp are creepy, even for her If the latest reports that Amber Heard had a strategic plan to blackmail Elon Musk to pay Johnny Depp the judgment against her, it’s the creepiest thing that we have seen from the actress during her very public spiral. And maybe the creepiest thing from Elon Musk, which says a lot. After starring in and…
- Woman’s body found in a suitcase in Puerto Vallarta On Saturday night, authorities located the body of a person inside a suitcase on Antonio J. Hernández street and Prolongación Zacatecas street in the Primero de Mayo neighborhood in the municipality of Puerto Vallarta. The report was made to the 911 emergency service where a suspicious package was mentioned on Antonio J. Hernández street at…
- Texas man dies at Blue Chairs Hotel in Puerto Vallarta Another unfortunate death was recorded in the Romantic Zone of Puerto Vallarta, where a 71-year-old man from Texas was found dead inside his hotel room at the Blue Chairs Hotel on Los Muertos Beach. It was announced that the man apparently died of natural causes, however, as there was no direct relative who could officially…